Key Colony Beach is located in the heart of the Florida Keys. While staying in one of our Key Colony Beach vacation rentals, you’ll enjoy direct access to the Gulf of Mexico and the Atlantic Ocean, beautiful coral reefs, excellent fishing and diving locations, and all the comforts of your own home. Key Colony Beach is about 50 miles driving distance to Key West, and it will take you about an hour and a half to get here from the mainland. Find your coastal vacation home in Key Colony Beach.